Journal Publications

[69] J. Mei, Y. Cai, O. Mussafi, M. Zheng, Y. Xu, R. Chen, G. Jiang, W. Mao, W. Xia, and Y. Wan*, . Submitted

[68] J. Wang, C. Lv, M. Zhou, J. Xu, B. Chen, and Y. Wan*, Second Primary Malignancy Risk In Multiple Myeloma From 1975 to 2018. Submitted

[67] J. Wang, Y. Zuo, C. Lv, M. Zhou, and Y. Wan*, Integrated Analysis of A Two-Gene Prognostic Signature Based On m6A Regulators for Multiple Myeloma. Submitted

[66] W. Mao, D. Tian, Y. Chen, R. Chen, M. Zheng, and Y. Wan*, Immune Landscape in Early Lung Adenocarcinoma By Transcriptome AnalysesSubmitted

[65] G. Wang, Y. Wan*, and Q. Li, Single-Cell Profiling of Heterogeneity in Lung Adenocarcinoma Cells During Consecutive Stage of Tumor Progression. Submitted

[64] R. Bai, E. Thoma, K. Schuck, Y. Wan, A. Mihaljevic, C. Michalski, and K. Bo, Projected Unfavourable Tumour Biology By Extracellular Matrix-Receptor At The Premalignant Stage of Pancreatic Cancer. Submitted

[63] G. Wang, J. Sun, J. Zhang, J. Lu, S. Gao, F. Wang, Q. Yin, Y. Wan*, and Q. Li, EOMES+CD8+ T Cell As A Potential Indicator for EGFR-TKI Resistance In Lung Cancer. Submitted

[62] G. Jiang, Y. Xu, Z. Quinn, S. Chen, R. Chen, S. Wang, W. Mao, Y. Wan*, and M. Zheng, Pan-Cancer Analysis of Mitosis-Related Gene CENPI: A Potential Target for Tumor Prognosis, Immunity, and Therapy. Submitted

[61] S. Chen, D. Tian, L. Petersen, S. Cao, Z. Quinn, J. Kan, M. Zheng, W. Mao, and Y. Wan*, Prognostic Value of GIMAP4 And Its Role In Promoting Immune Cells Infiltration Into Tumor Microenvironment of Lung Adenocarcinoma. Biomed Res Int

[60] O. Mussafi, J. Mei, W. Mao, and Y. Wan*, Immune Checkpoint Inhibitors for PD-1/PD-L1 Axis in Combination with Other Immunotherapies and Targeted Therapies for Non-Small Cell Lung Cancer, Front Oncol, (2022) [Link]

[59] Y. Wan*, Y. Xia, and S. Zheng, Extruded Small Extracellular Vesicles: Splinters of Circulating Tumor Cells May Promote Cancer Metastasis?, Br J Cancer, (2022) [Link]

[58] L. Yong, S. Tang, H. Yu, H. Zhang, Y. Zhang, Y. Wan*, and F. Cai, The Role of Hypoxia-Inducible Factor-1Alpha in Multidrug-Resistant Breast Cancer. Front Oncol, (2022) 12:964934 [Link]

[57] J. Mei, G. Jiang, Y. Chen, Y. Xu, Y. Wan, R. Chen, F. Liu, W. Mao, M. Zheng, and J. Xu, HLA Class II Molecule HLA-DRA Identifies Immuno-Hot Tumors and Predicts The Therapeutic Response to Anti-PD-1 Immunotherapy. BMC Cancer, (2022) 22:738 [Link]

[56] Y. Wen, Q. Fu, A. Soliwoda, S. Zhang, M. Zheng, W. Mao, and Y. Wan*, Cell-Derived Nanovesicles Prepared By Membrane Extrusion Are Good Substitutes For Natural Extracellular Vesicles. Extracell Vesicles, (2022) 1:100004 [Link]

[55] Y. Chen, Y. Xu, J. Wang, P. Prisinzano, Y. Yuan, F. Lu, M. Zheng, W. Mao, and Y. Wan*, Statins Lower Lipid Synthesis But Promote Secretion of Cholesterol-Enriched Extracellular Vesicles and Particles. Front Oncol, (2022) 12:853063 [Link]

[54] J. Wang, C. Lv, M. Zhou, J. Xu, B. Chen, and Y. Wan*, Primary Central Nervous System Lymphoma in the United States, 1975-2017. Ther Adv Hematol(2022) 13:1-9 [Link]

[53] Y. Chen, L. Wang, M. Zheng, C. Zhu, G. Wang, Y. Xia, E. Blumenthal, W. Mao, and Y. Wan*, Engineered Extracellular Vesicles for Concurrent Anti-PDL1 Immunotherapy and Chemotherapy. Bioact Mater, (2022) 9:251-265 [Link]

[52] G. Wang, W. Hu, Y. Chen, Y. Wan*, and Q. Li, Integrated mPD-L1 and Metabolic Analysis Identifies New Prognostic Subgroups in Lung Cancers with Wild-Type EGFR. Clin Transl Med(2021) 11: e612 [Link]

[51] Z. Zhang, H. Li, Y. Deng, K. Schuck, S. Raulefs, N. Maeritz, Y. Yu, T. Hechler, A. Pahl, V. Fernandez-Saiz, Y. Wan, G. Wang, T. Engleitner, R. Ollinger, R. Rad, M. Reichert, K. Diakopoulos, V. Weber, J. Li, S. Shen, X. Zou, J. Kleeff, A. Mihaljevic, C. Michalski, H. Algul, H. Friess, and B. Kong, AGR2-Dependent Nuclear Import of RNA Polymerase II Constitutes A Specific Vulnerable Target of Human Cancers Bearing Wild-Type P53Gastroenterology(2021) 161:1601-1614 [Link]

[50] H. Zhang, X. Lin, Y. Huang, M. Wang, C. Cen, S. Tang, M. Dique, L. Cai, M. Luis, J. Smollar, Y. Wan, and F. Cai, Detection Methods and Clinical Applications of Circulating Tumor Cells in Breast CancerFront Oncol(2021) 11:652253 [Link]

[49] Y. Liu, Y. Xia, J. Smollar, W. Mao, and Y. Wan*, The Roles of Small Extracellular Vesicles in Lung Cancer: Molecular Pathology Mechanisms, Diagnostics, and TherapeuticsBiochim Biophys Acta Rev Cancer(2021) 1876:188539 [Link]

[48] K. Abhange, A. Makler, Y. Wen, N. Ramnauth, W. Mao, W. Asghar, and Y. Wan*, Small Extracellular Vesicles in CancerBioact Mater(2021) 6:3705-3743 [Link]

​[47] Q. Zheng, H. Ding, L. Wang, Y. Yan, Y. Wan, Y. Yi, L. Tao, and C. Zhu, Circulating Exosomal miR-96 As A Novel Biomarker for Radioresistant Non-Small-Cell Lung CancerJ Oncol(2021) 2021:5893981 [Link]

[46] Y. Chen, F. Xue, A. Russo, and Y. Wan*, Proteomic Analysis of Extracellular Vesicles Derived from MDA-MB-231 Cells in MicrogravityProtein J(2021) 40:108-118 [Link]

[45] Z. Quinn, W. Mao, Y. Chen, G. Wang, Y. Xia, R. John, and Y. Wan*, Conferring Receptors on Recipient Cells with Extracellular Vesicles for Targeted Drug DeliveryBioact Mater(2021) 6:749-756 [Link]

​[44] F. Xue, Y. Chen, Y. Wen, K. Abhange, W. Zhang, G. Cheng, Z. Quinn, W. Mao, and Y. Wan*, Isolation of Extracellular Vesicles with Multivalent AptamerAnalyst(2021) 146: 253-261 [Link]

​[43] J. Wang, M. Zhou, J. Xu, R. Zhou, B. Chen, and Y. Wan*, Comparison of Antifungal Prophylaxis Drugs in Patients with Hematological Disease or Undergoing Hematopoietic Stem Cell Transplantation: A Systematic Review and Network Meta-AnalysisJAMA Network Open, (2020) 3:e2017652 [Link]

[42] W. Hu, G. Wang, L. Yarmus, and Y. Wan*, Combined Methylome and Transcriptome Analyses Reveals Potential Therapeutic Targets for EGFR Wild Type Lung Cancers with Low PD-L1 ExpressionCancers, (2020) 12:2496 [Link]

[41] W. Hu, G. Wang, L. An, Y. Chen, L. Yarmus, B. Liu, and Y. Wan*, Coupled Immune Stratification and Identification of Therapeutic Candidates in Patients with Lung AdenocarcinomaAging, (2020) 12:16514-16538 [Link]

[40] Y. Wen, Y. Chen, G. Wang, K. Abhange, F. Xue, Z. Quinn, W. Mao, and Y. Wan*, Factors Influencing Measurement the Secretion Rate of Extracellular VesiclesAnalyst, (2020) 145:5870-5877 [Link]

[39] L. Wang, K. Abhange, Y. Wen, Y. Chen, F. Xue, G. Wang, J. Tong, C. Zhu, X. He, and Y. Wan*, Preparation of Engineered Extracellular Vesicles Derived from Human Umbilical Cord Mesenchymal Stem Cells with Ultrasonication for Skin RejuvenationACS Omega, (2019) 4:22638-22645 [Link]

[38] W. Mao, Y. Wen, H. Lei, R. Lu, S. Wang, Y. Wang, R. Chen, Y. Gu, L. Zhu, K. Abhange, Z. Quinn, Y. Chen, F. Xue, M. Zheng, and Y. Wan*, Isolation and Retrieval of Extracellular Vesicles for Liquid Biopsy of Malignant Ground-Glass Opacity. Anal Chem, (2019) 91(21):13729-13736 [Link]

​[37] Y. Wan, M. Maurer, H. He, Y. Xia, W. Zhang, N. Yee, and S. Zheng, Enrichment of Extracellular Vesicles Using Lipid Nanoprobes Functionalized Nanostructured SilicaLab Chip, (2019) 19:2346-2355 [Link]

[36] Y. Wan* and S. Zheng, Enhanced Detection of Tumor-Secreted Vesicles. Nat Biomed Eng, (2019) 3(6):421-422 (News & Views, Invited) [Link]

[35] Y. Xia, Y. Wan, S. Hao, R. A. Harouaka, and S. Zheng, Nucleus of Circulating Tumor Cell Determines Its Translocation Through Biomimetic Microconstrictions and Its Physical Enrichment by MicrofiltrationSmall, (2018) 14(44):e1802899 [Link]

[34] Y. Wan, B. Liu, H. Lei, B. Zhang, Y. Wang, H. Huang, S. Chen, Y. Feng, L. Zhu, Y. Gu, Q. Zhang, H. Ma, and S. Zheng, Nanoscale Extracellular Vesicle-derived DNA is Superior to Circulating Cell Free DNA for Mutation Detection in Early-stage Non-Small Cell Lung CancerAnn Oncol, (2018) 29(12):2379-2383 [Link]

[33] G. Cheng, W. Li, L. Ha, X. Han, S. Hao, Y. Wan, Z. Wang, F. Dong, X. Zou, Y. Mao, and S. Zheng, Self-assembly of Extracellular Vesicle-like Metal-organic Framework Nanoparticles for Protection and Intracellular Delivery of Bio-functional ProteinJ Am Chem Soc, (2018) 140(23):7282-7291 [Link]

[32] S. Hao, Y. Wan, Y. Xia, and S. Zheng, Size-based Separation Methods of Circulating Tumor CellsAdv Drug Deliv Rev, (2018) 125:3-20 (Invited review, Equal Contribution First Author) [Link]

[31] Y. Wan, L. Wang, C. Zhu, G. Wang, Y. Fang, Y. Xia, J. Tong, X. He, and S. Zheng, Aptamer Conjugated Extracellular Nanovesicles for Targeted Drug DeliveryCancer Res, (2018) 78(3):798-808 [Link]

[30] W. Li, Z. Wang, S. Hao, L. Sun, M. Nisic, G. Cheng, C. Zhu, Y. Wan, L. Ha, and S. Zheng, Mitochondria-based aircraft carrier enhances in vivo imaging of carbon quantum dots and delivery of anticancer drugNanoscale, (2018) 10(8):3744-3752 [Link]

[29] S. Hao, L. Ha, G. Cheng, Y. Wan, Y. Xia, D. Sosnoski, A. Mastro, and S. Zheng, A Spontaneous 3D Bone-on-a-chip for Bone Metastasis Study of Breast Cancer CellsSmall(2018) 14(12):e1702787 [Link]

[28] C. Zhu, L. Wang, Y. Cai, G. Wang, H. Xu, Y. Wan*, and Q. Zheng, Enhancement of Radiation Effect on SMCC7721 Cell through Endoplasmic Reticulum Stress Induced in vitro and in vivo by C225-GNPsOncol Lett, (2018) 15(4):4221-4228 [Link]

[27] W. Li, L. Sun, Y. Xia, S. Hao, G. Cheng, Z. Wang, Y. Wan, C. Zhu, H. He, and S. Zheng, Pre-occupation of Empty Carriers Decreases Endo/Lysosome Escape and Reduces the Protein Delivery Efficiency of Mesoporous Silica NanoparticlesACS Appl Mater Interfaces, (2018) 10(6):5340-5347 [Link]

[26] Y. Xia, Y. Tang, X. Yu, Y. WanY. Chen, H. Lu, and S. Zheng, Label-free Virus Capture and Release by a Microfluidic Device Integrated with Porous Silicon Nanowire ForestSmall, (2017) 13:1603135, Cover Article [Link]

[25] W. Li, Z. Wang, S. Hao, H. He, G. Cheng, Y. Wan, C. Zhu, L. Sun, G. Cheng and S. Zheng, Mitochondria-targeting Polydopamine Nanoparticles to Deliver Doxorubicin for Overcoming Drug ResistanceACS Appl Mater Interfaces, (2017) 9(20):16793-16802 [Link]

[24] Y. Wan, G. Cheng, X. Liu, S. Hao, M. Nisic, C. Zhu, Y. Xia, W. Li, Z. Wang, W. Zhang, S. Rice, A. Sebastian, I. Albert, C. Belani, and S. Zheng, Rapid Isolation of Extracellular Vesicles via Lipid-based NanoprobesNat Biomed Eng, (2017) 1(4):0058, Front Cover [Link]

[23] H. Ding, M. Su, C. Zhu, L. Wang, Q. Zheng, and Y. Wan*, CT-guided verses Laparoscopic Radiofrequency Ablation in Recurrent Hepatocellular Carcinoma against the Diaphragmatic DomeSci Rep, (2017) 7:44583 [Link]

[22] G. Cheng, S. Hao, Y. Wan, D. Shan, J. Yang and S. Zheng, Self-assembly of Smart Multifunctional Hybrid Compartments with Programmable BioactivityChem Mater, (2017) 29(5):2081-2089 [Link]

[21] W. Ali, M.U. Raza, M.A.I. Mahmood. P.B. Allen, A.R. Hall, Y. Wan, and S.M. Iqbal, Differentiation of Specific Cacner Biomarkers with Solid-state NanoporesFunc Nanostruct, (2016) 26-34 [Link]

[20] C. Zhu, Q. Zheng, L. Wang, H. Xu, J. Tong, Q. Zhang, Y. Wan*, and J. Wu, Synthesis of Novel Galactose Functionalized Gold Nanoparticles and Its Radiosensitizing MechanismJ Nanobiotechnology, (2015) 13:67​ [Link]

[19] H. Ma, J. Liu, M. Ali, F. Li, M. A. I. Mahmood, L. Labanieh, M. Mu, S. M. Iqbal, Q. Zhang, W. Zhao, and Y. Wan*, Nucleic Acid Aptamers in Cancer Research, Diagnosis and TherapyChem Soc Rev, (2015) 44(5):1240-1256 [Link]

[18] M. A. I. Mahmood, Y. Wan, M. Islam, W. Ali, M. Hanif, Y. Kim, and S. M. Iqbal, Micro + Nanotexturing of Substrates to Enhance Ligand-assisted Cancer Cell IsolationNanotechnology, (2014) 25(47):475102 [Link]

[17] S. Wang, Y. Wan* and Y. Liu, Effects of Nanopillar Array Diameter and Spacing on Cancer Cell Capture and Cell BehaviorsNanoscale, (2014) 6(21):12482-9, Front Cover [Link]

[16] Y. Wan, M. Winter, B. Delalat, N. H. Voelcker, and B. Thierry, Nanostructured Polystyrene Well Plates Allow Unbiased High-throughput Characterization of Circulating Tumor CellsACS Appl Mater Interfaces, (2014) 6(23):20828-20836 [Link]

[15] Y. Wan, S. Apostolou, R. Dronov, B. Kuss, and N. H. Voelcker, Cancer-targeting siRNA Delivery from Porous Silicon NanoparticlesNanomedicine, (2014) 9(15):2309-2321 [Link]

[14] Q. Zheng, S. M. Iqbal, and Y. Wan*, Cell Detachment: Post-isolation Challenge, Biotechnol Adv, (2013) 31(8):1664-1675 [Link]

[13] Y. Wan, D. Tamuly, P. B. Allen, Y.-T. Kim, R. Bachoo, A. D. Ellington and S. M. Iqbal, Proliferation and Migration of Tumor Cells in Tapered ChannelsBiomed Microdevices(2013) 15(4):635-643 [Link]

[12] L. Wang, W. Asghar, Utkan Demirci, and Y. Wan*, Nanostructured Substrates for Circulating Tumor Cell IsolationNano Today, (2013) 8(4):374-387 [Link]​

[11] L. Wang, Q. Zheng, Q. Zhang, H. Xu, J. Tong, C. Zhu and Y. Wan*, Detection of Single Tumor Cell Resistance with Aptamer BiochipOncol Lett, (2012) 4(5):935-940 [Link]​

[10] Y. Wan, Y. Liu, P. B. Allen, W. Asghar, M. A. I. Mahmood, J. Tan, H. Duhon, Y.-t. Kim, A. D. Ellington and S. M. Iqbal, Capture, Isolation and Release of Cancer Cells with Aptamer-functionalized Glass Bead ArrayLab Chip(2012) 12(22):4693-701, Cover Article [Link]

[9] W. Asghar, Y.-t. Kim, A. Ilyas, J. S. Sankaran, Y. Wan, P. Abhyankar, and S. M. Iqbal, Synthesis of Nano-textured Biocompatible Scaffolds from Chicken EggshellsNanotechnology, (2012) 23(47):475601 [Link]

[8] W. Asghar, Y. Wan, A. Ilyas, Y.-t. Kim and S. M. Iqbal, Electrical Fingerprinting, 3D Profiling and Detection of Tumor Cells with Solid-state MicroporesLab Chip, (2012) 12(13):2345-2352, Cover Article [Link]

[7] W. Asghar, M. Islam, A. S. Wadajkar, Y. Wan, A. Ilyas, K. T. Nguyen and S. M. Iqbal, PLGA Micro and Nanoparticles Loaded into Gelatin Scaffold for Controlled Drug ReleaseIEEE Trans Nanotechnol, (2012) 11(3):546-553, Front Cover [Link]

[6] Y. Wan, J. Tan, W. Asghar, Y.-t. Kim, Y. Liu and S. M. Iqbal, Velocity Effect on Aptamers-based Circulating Tumor Cell Isolation in Microfluidic DevicesJ Phy Chem B, (2011) 115(47):13891-13896 [Link]

[5] Y. Wan, M. A. I. Mahmood, N. Li, P. B. Allen, Y.-t. Kim, R. Bachoo, A. D. Ellington and S. M. Iqbal, Nanotextured Substrates with Immobilized Aptamers for Cancer Cell Isolation and CytologyCancer, (2011) 118(4):1145-1154 [Link]

[4] Y. Wan, Y.-t. Kim, N. Li, S. K. Cho, R. Bachoo, A. D. Ellington and S. M. Iqbal, Surface Immobilized Aptamers for Cancer Cell Isolation and Microscopic CytologyCancer Res, (2010) 70(22):9371-9380 [Link]

[3] Y. Wan, Y. Wang, J. Luo, and Z. Lu, Bisulfite Modification of Immobilized DNAs for Methylation DetectionBiosens Bioelectron, (2007) 22(11):241524-21 [Link]

[2] P. Xiao, L. Cheng, Y. Wan, B. Sun, Z. Chen, S. Zhang, C. Zhang, G. Zhou, and Z. Lu, An improved gel-based DNA microarray method for detecting single nucleotide mismatchElectrophoresis(2006) 27(19):3904-3915 [Link]

[1] D. Zhou, W. Qiao, Y. Wan, and Z. Lu, Microarray-based Methylation Analysis Using Dual-color Fluorescence Hybridization. J Biochem Biophys Methods(2006) 66:33-43 [Link]

Conference Proceedings

[37] L. Tong and Y. Wan, Automatic Circulating Tumor Cell Segmentation and Eneureation in Digital Pathology by Using Deep Learning and Ball-Scale Based Filtering Techniques, at IEEE Singal Processing in Medicine and Biology Symposium, Philadelphia, PA USA (December 3, 2022)

[36] Y. Wen and Y. Wan, Natural Extracellular Vesciels and Extruded Nanovesicles Have Highly Similar Membrane Protein Profiles, at Biomedical Engineering Society Annual Meeting, San Antonio, TX, USA (October 12-15, 2022)

[35] Y. Chen, M. Rahman, and Y. Wan, Construction of Tumor-Targeted Fusogenic Extracellular Vesicles for Cytosolic Delivery of Drugs, at ASEMV2022/AAEV2022, Pacific Grove, CA, USA (September 29-October 3, 2022)

[34] Y. Chen, Y. Wen, E. Blumenthal, K. Abhange, and Y. Wan, Anti-PD-L1 Extracellular Vesicles for Cancer Combination Therapy, at Biomedical Engineering Society Virtual Annual Meeting, (October 6-9, 2021)

[33] Y. Wen, Y. Chen, K. Abhange, F. Xue, and Y. Wan, The Secretion Rate of Extracellular Vesicles and The Related Interfering Factors, at Biomedical Engineering Society Virtual Annual Meeting, (October 14-17, 2020)

[32] F. Xue, Z. Quinn, Y. Chen, R. Joh, and Y. Wan, Conferring Receptors  on Cancer Cells with Extracellular Vesicles for Targeted Therapy, at 3rd Carnegie Mellon Forum on Biomedical Engineering, Pittsburgh, PA, USA (September 18-19, 2020)

[31] K. Komal, Y. Wen, Y. Chen, F. Xue, and Y. Wan, The Impact of Simulated Microgravity on Physiochemical Characteritics of MDA-MB-231 Extracellular Vesicles, at 46th Annual Northeast Bioengineering Conference, State College, PA, USA (March 26-28, 2020)

[30] S. Zheng, H. He, F. Wang, and Y. Wan, Extracellular Vesicle-Based Liquid Biopsy via Lipid-Based Nanoprobes, at AACR Special Conference on Advances in Liquid Biopsies, Miami, FL, UAS (January 13-16)

[29] S. Zheng, Y. Wan, M. Maurer, Y. Xia, S. Hao, W. Zhang, and N. Yee, Microfluidic Device Integrated with Lipid Nanoprobe for Extracellular Vesicle Isolation toward Non-invasive Cancer Diagnosis, at AACR Annual Meeting, Atlanta, GA, USA (March 29-April 3, 2019)

[28] D. Bordena, Y. Wen, K. Abhange, Y. Chen, F. Xue, and Y. Wan, Stimulated Microgravity Influences the Size and Release Rate of Extracellular Vesicles,  at Biomedical Engineering Society Annual Meeting, Philadelphia, PA, USA (October 16-19, 2019)

[27] Y. Wen, K. Abhange, and Y. Wan, Extracellular Vesicles-based Liquid Biopsy of Pulmonary Ground Glass Opacity, at Biomedical Engineering Society Annual Meeting, Philadelphia, PA, USA (October 16-19, 2019)

[26] K. Abhange, Y. Wen, and Y. Wan, Human Umbilical Cord Mesenchymal Stem Cell Derived Engineered Extracellular Vesicles for Skin Rejuvenation, at Biomedical Engineering Society Annual Meeting, Philadelphia, PA, USA (October 16-19, 2019)

[25] Y. Xia, Y. Wan, Y. Chen, and S. Zheng, Mechanical Generated Extracellular Vesicles through Capillary Mimicking Micro Channels, at Biomedical Engineering Society Annual Meeting, Philadelphia, PA, USA (October 16-19, 2019)

[24] M. Maurer, Y. Wan, H. He, Y. Xia, S. Hao, W. Zhang, N. Yee, and S. Zheng, Enrichment of Extracellular Vesicles via Lipid Nanoprobe-Functionalized Nanostructured Silica Microdevice, at Transducer 2019/EUROSENSORS XXXIII Conference: The 20th International Conference on Solid-State Sensors, Actuators and Microsystems, Estrel Berlin, Germany (June 23-27, 2019)

[23] Y. Wan, M. Maurer, H. He, Y. Xia, W. Zhang, S. Hao, N. Yee, and S. Zheng, A microfluidic Device with Nanoscale Surface Topology and Functionalized with Lipid Nanoprobes for Extracellular Vesicles Isolation and Clinical Cancer Diagnosis, at ISEV 2019, Kyoto, Japan (April 25-28, 2019)

[22] Y. Wen, K. Abhange, and Y. Wan, Rapid and Efficient Isolation of Extracellular Vesicles Towards Clinical Translation, at The 12th Annual Binghamton Biomedical Research Conference, Binghamton, NY, USA (March 23, 2019)

[21] Y. Wen, K. Abhange, and Y. Wan, Detection of DNA Mutations in Extracellular Vesicles Derived from Patients with Malignant Ground Glass Opacities, at The 45th Annual Northeast Bioengineering Conference, New Brunswich, NJ, USA (March 20-22, 2019)

[20] K. Abhange, Y. Wen, and Y. Wan, Engineered Extracellular Vesicles Derived from Human Umbilical Cord Mesenchymal Stem Cells for Skin Rejuvenation, at The 45th Annual Northeast Bioengineering Conference, New Brunswich, NJ, USA (March 20-22, 2019)

[19] Y. Wen, K. Abhange, and Y. Wan, Next Generation Sequencing Analysis of Extracellular Vesicles Derived DNA from 8 Patients with Ground-Glass Opacity, at Translational Genomics & Proteomics: An Un-Meeting, Rochester, NY, USA (March 13, 2019)

[18] M. Maurer, Y. Wan, H. He, Y. Xia, S. Hao, W. Zhang, N. Yee, and S. Zheng, Lipid-Nanoprobe Functionalized Silica Nanostructured Microdevice for Exosome Enrichment, at Biomedical Engineering Society Annual Meeting, Atlanta, Georgia, USA (October 17-20, 2018)

[17] Y. Xia, Y. Wan, S. Hao, and S. Zheng, Nuclei’s Role in Cell Translocation Through Micro-restrictions, at 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2017 Conference, Savannah, Georgia, USA (October 22-26, 2017)

[16] Y. Wan and S. Zheng, Rapid Isolation of Extracellular Vesicles with Lipid Nanoprobes, at Biomedical Engineering Society Annual Meeting, Phoenix, Arizona, USA (October 11-14, 2017)

[15] G. Cheng, S. Hao, Y. Wan, and S. Zheng, Self-assembly of Smart Multifunctional Hybrid Compartments with Programmable Bioactivity, at Biomedical Engineering Society, Phoenix, Arizona, USA (October 11-14, 2017)

[14] G. Cheng, S. Hao, Y. Wan, D. Shan, J. Yang and S. Zheng, Smart Magnetic Colloidosomes as Multifunctional Microreactors for Programming Biomolecular Activity, at 254th American Chemical Society National Meeting & Exposition, Washington, DC, USA (August 20-24, 2017)

[13] S. Hao, G. Cheng, Y. Wan and S. Zheng, A Bone-on-a-chip Microdevice for Long-term Spontaneous 3D Bone Tissue Formation and Cancer Bone Metastasis, at 19th International Conference on Solid-State Sensors, Actuators and Microsystems, Kaohsiung, Taiwan (June 18-22, 2017)

[12] Q. Zheng, H. Ding, C. Zhu, L. Wang, and Y. Wan*, Retrospective Study of CT-guided verses Laparoscopic Radiofrequency Ablation in Recurrent Hepatocellular Carcinoma against the Diaphragmatic Dome, at Gastrointestinal Cancers Symposium, San Francisco, California, USA (January 19-21, 2017)

[11] Q. Zheng, H. Ding, C. Zhu, L. Wang, and Y. Wan*, CT-guided verses Laparoscopic Radiofrequency Ablation in Recurrent Hepatocellular Carcinoma against the Diaphragmatic Dome, at ESMO Asia, Singapore, (December 16-19, 2016)

[10] S. Wang, Y. Wan, Y. Liu, Effects of Nanopillar Array Geometry on Capture and Detachment of Circulating Tumor Cells, at 7th World Congress of Biomechanics, Boston, MA, USA (July 6-11, 2014)

[9] Y. Wan and B. Thierry, Rapid and Efficient Binding of Cancer Cells on Nanostructured Polystyrene for Morphological and Molecular Analysis, at 23rd Australian Conference on Microscopy and Microanalysis (ACMM23) and the International Conference on Nanoscience and Nanotechnology (ICONN), Adelaide, SA, Australia (February 2-6, 2014)

[8] Y. Wan, S. Apostolou, B. Kuss, R. Dronov and N.H. Voelcker, Amino-functionalized Porous Silicon Nanoparticles for Loading and Release of siRNA, at 22nd ASBTE with 5th Indo-Australian Conference on Biomaterials, Implants and Tissue Engineering, Barossa Valley, SA, Australia (April 2-5, 2013)

[7] M. A. I. Mahmood, U. J. M. Khan, Y. Wan, Y.-t. Kim and S. M. Iqbal, Metastatic Tumor Cells Show Distinct Behavior on Aptamer Functionalized Chips, at Biomedical Engineering Society Annual Meeting, Atlanta, GA, USA (October 24-27, 2012)

[6] Y. Wan, Y.-t. Kim, N. Li, A. D. Ellington, R. Bachoo and S. M. Iqbal, Novel Solid-State Coatings for Cancer Cell Isolation and Cytology, at 27th Southern Biomedical Engineering Conference (SBEC), Arlington, TX, USA (April 29-May 1, 2011)

[5] Y. Wan, Y.-t. Kim, N. Li, A. D. Ellington, R. Bachoo and S. M. Iqbal, Surface texturing and molecular functionalization for cancer cell isolation, at World’s Best Technologies Innovation Marketplace, Arlington, TX, USA (March 22-23, 2011)

[4] R. A. Khan, W. Asghar, Y. Wan, and S. M. Iqbal, Single Pore System for Classification of Cells, at Biomedical Engineering Society Annual Meeting, Austin, TX, USA (October 6-9, 2010)

[3] Y. Wan, Y.-t. Kim, N. Li, A. D. Ellington and S. M. Iqbal, Aptamer-based Lab-on-Chip for Cancer Cell Isolation and Detection, at Proc. of ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology (NEMB 2010), Houston, TX, USA (February 7-10, 2010)

[2] Y. Wang, Y. Wan, W. Zheng, Z. Lu, The Feasibility of in situ Bisulfate Modification for Genomic DNA Methylation Detection, at Proc. of 4 thInternational Forum on Post-genome Technologies, Hangzhou, China (September 25-26, 2006)

[1] Y. Wan, Y. Wang, J. Luo and Z. Lu, Detection of p16 Promoter Methylation Using Acrylamide Modified Nucleic Acids Microarray, in Proc. of 4thInternational forum on post-genome technologies, Hangzhou, China (September 25-26, 2006)

Book Chapter

[2] Y. Wan, M. Maurer, S. Zheng, Affinity-Based Enrichment of Extracellular Vesicles with Lipid Nanoprobes. Biomed Eng Technol, (2022) 185-197 [Link]

[1] M. A. I. Mahmood, Y. Wan, and S. M. Iqbal, Micro/Nanostructured Substrates for Cancer Cell Typing, Isolation and Disease Diagnostics in Nanotechnology, Biosensors and Disease Biomarkers: New Approaches to enable Personalized, Preventative and At-Home Medicine, Editors: M. J. A. Shiddiky and M. Trau, Nova Science Publishers Inc., USA (2013)​

Invited Talks & Seminars

[7] "Small Extracellular Vesicles As Diagnostic and Therapeutic Tools", George Mason University, Apr 14, 2022

[6] "Small Extracellular Vesicles As Diagnostic and Therapeutic Tools", Brigham and Women's Hospital, Engineering in Medicine Division, Harvard Medical School, Mar 23, 2022

[5] "Small Extracellular Vesicles As Diagnostic and Therapeutic Tools", Rutgers University, Mar 4, 2022

[4] "Early Diagnosis of Malignant Pulmonary Nodules" Trial Site News, Dec 6 2021

[3] "Optimal Antifungal Prophylactic Agents for Patients with Hematologic Diseases". i3Health News, Oct 9, 2020

[2] "Extracellular Vesicles in Cancer Diagnostics and Therapeutics", Northeast BME Early-Career Faculty Seminar, at Stevens Institute of Technology, Nov 19, 2019.

[1] "Extracellular Vesicles in Cancer Diagnostics and Therapeutics", Graduate Seminar, Binghamton University, Sep 24, 2018

Patents

[4] Y. Wan, Variant Human PD-1 Overexpressing Extracellular Vesicles for Concurrent Immunotherapy and Chemotherapy, RB663

[3] S. Zheng, Y. Wan, and G. Cheng, Lipid Nanoprobes for Isolation of Extracellular Vesicles, US Patent App. No. PCT/US2017/064634 

[2] S. Iqbal, S. Goyal, Y. Kim, Y. Wan, M.A.I. Mahmood, and U.J.M. Khan, Methods of Detection Tumor Cells, US Patent App. No. US2015/0010912

[1] S. Iqbal, S. Goyal, Y. Kim, and Y. Wan, Nano-scale Biosensors, US Patent No. US8940663