Representative Publications
M. Rahman, J. Wang, G. Wang, Z. Su, Y. Li, Y. Chen, J. Meng, Y. Yao, L. Wang, S. Wilkens, J. Tan, J. Luo, T. Zhang, C. Zhu, L. Wang, L. Lee, and Y. Wan*, Chimeric Nanobody-Decorated Liposomes by Self-Assembly. Nat Nanotech, (2024) 19:818-824 (IF: 39.9)
L. Wang, W. Mao, G. Wang, Y. Chen, M. Rahman, P. Prisinzano, B. Kong, J. Wang, L. Lee, and Y. Wan*, Bioinspired Engineering of Fusogen and Targeting Moiety Equipped Nanovesicles. Nat Comm, (2023) 14: 3366 (IF: 16.1)
Y. Wan, B. Liu, H. Lei, B. Zhang, Y. Wang, H. Huang, S. Chen, Y. Feng, L. Zhu, Y. Gu, Q. Zhang, H. Ma, and S. Zheng, Nanoscale Extracellular Vesicle-derived DNA is Superior to Circulating Cell Free DNA for Mutation Detection in Early-stage Non-Small Cell Lung Cancer. Ann Oncol, (2018) 29(12):2379-2383 (IF: 38.2)
Y. Wan, G. Cheng, X. Liu, S. Hao, M. Nisic, C. Zhu, Y. Xia, W. Li, Z. Wang, W. Zhang, S. Rice, A. Sebastian, I. Albert, C. Belani, and S. Zheng, Rapid Isolation of Extracellular Vesicles via Lipid-based Nanoprobes. Nat Biomed Eng, (2017) 1(4):0058, Front Cover (IF: 29.2)
H. Ma, J. Liu, M. Ali, F. Li, M. A. I. Mahmood, L. Labanieh, M. Mu, S. M. Iqbal, Q. Zhang, W. Zhao, and Y. Wan*, Nucleic Acid Aptamers in Cancer Research, Diagnosis and Therapy. Chem Soc Rev, (2015) 44(5):1240-1256 (IF: 48.1)
Journal Publications
[90] C. Wang, H. Gu, J. Cai, C. Zhu, Q. Zheng, H. Xu, L. Wang, and Y. Wan*, Enhanced Detection of Circulating Tumor Cells Using A MUC1 Promoter-Driven Recombinant Adenovirus. Submitted (2024)
[89] J. Wang, D. Zhou, C. Lv, M. Zhou, R. Zhou, and Y. Wan*, The Effects of Coagulation Factors On the Risk of Pulmonary Embolism: Mendelian Randomization Analyses and A Retrospective Cohort Study. Submitted (2024)
[88] X. Zou, S. Nie, J. Cao, M. Shi, K. Schuck, Z. Shi, L. Zhang, H. Li, Y. Sun, C. Fang, J. Hu, Y. Niu, Y. Yu, Z. Zhang, C. Li, M. Hu, L. Wang, K. Jiang, Z. Lu, J. Akkan, S. Raulefs, C. Kahlert, S. Roth, I. Herr, Y. Wan, A. Mihaljevic, X. Qian, Q. Zhang, M. Wang, J. Kleeff, H. Friess, Z. Gu, C. Michalski, S. Shen, and B. Kong, ALDH1A3 Promotes the Aggressive Basal-like Pancreatic Cancer Phenotype Through An AP-1/RUNX2-Driven Enhancer Network. Submitted (2024)
[87] G. Jiang, X. Wang, W. Liu, D. Tian, Z. He, C. Song, J. Liu, R. Chen, M. Zheng, Y. Wan*, and W. Mao, Profiling Dynamic Immune Landscape in Early Evolution of Lung Adenocarcinoma from the Perspective of Epithelial-Mesenchymal Transition by Integrating Bulk, Single-Cell, and Spatial Transscriptomics Sequencing. Submitted (2024)
[86] M. Rahman, L. Wang, Y. Chen, L. Lee, and Y. Wan*, Rapid in situ Mutation Detection in Extracellular Vesicle-DNA. Submitted (2024)
[85] J. Liu, L. Wu, A. Xie, W. Liu, Z. He, Y. Wan*, and W. Mao, Unveiling the New Chapter In Nanobody Engineering: From Traditional Construction To AI-Driven Optimization. J Nanobiotechnology, (2025) [Link]
[84] L. Xie, Y. Xu, M. Zheng, Y. Chen, M. Sun, W. Mao, and Y. Wan*, An Anthropomorphic Diagnosis System of Pulmonary Nodules using Weak Annotation-Based Deep Learning. Comput Med Imaging Graph, (2024) 118:102438 [Link]
[83] Y. Chen, L. Wang, X. Yu, W. Mao, and Y. Wan*, Ultrasonication Outperforms Electroporation for Extracellular Vesicle Cargo Depletion. Extracell Vesicles, (2024) 4:100052 [Link]
[82] Z. Pi, W. Liu, C. Song, C. Zhu, J. Liu, L. Wang, Z. He, C. Yang, L. Wu, T. Liu, Z. Geng, S. Tebbutt, N. Liu, Y. Wan*, F. Zhang, and W. Mao, Multi-Level Insights into the Immuno-Oncology-Microbiome Axis: From Biotechnology to Novel Therapies. iMeta, (2024) e240 [Link]
[81] Y. Chen, S. Tang, F. Cai, and Y. Wan*, Strategies for Small Extracellular Vesicle-Based Cancer Immunotherapy. SPJ Research, (2024) 7:0421 [Link]
[80] J. Liu, W. Liu, Y. Wan*, and W. Mao, Crosstalk Between Exercise and Immunotherapy: Current Understanding and Future Directions. SPJ Research, (2024) 7:0360 [Link]
[79] J. Shi, R. Li, Y. Wang, C. Zhang, X. Lyu, Y. Wan, and Z. Yu, Detection of Lung Cancer through SERS Analysis of Serum. Spectrochim Acta A Mol Biomol Spectrosc, (2024) 314:124189 [Link]
[78] W. Liu, Z. Pi, X. Wang, C. Shang, C. Song, R. Wang, Z. He, Y. Wan*, and W. Mao, Microbiome and Lung Cancer: Carcinogenic Mechanisms, Early Cancer Diagnosis, and Promising Microbial Therapies. Crit Rev Oncol Hematol, (2024) 196:104322 [Link]
[77] C. Song, Y. Sun, Y. Chen, Y. Shen, H. Lei, W. Mao, J. Wang, and Y. Wan*, Differential Diagnosis of Pulmonary Nodules and Prediction of Invasive Adenocarcinoma Using Extracellular Vesicle DNA. Clin Transl Med, (2024) 14:e1582 [Link]
[76] M. Rahman, J. Wang, G. Wang, Z. Su, Y. Li, Y. Chen, J. Meng, Y. Yao, L. Wang, S. Wilkens, J. Tan, J. Luo, T. Zhang, C. Zhu, L. Wang, L. Lee, and Y. Wan*, Chimeric Nanobody-Decorated Liposomes by Self-Assembly. Nat Nanotech, (2024) 19:818-824 [Link]
[75] C. Song, W. Liu, Y. Wan*, and W. Mao, Editorial: Novel Insights into the Immunotherapy and Multimodality Therapy for Lung Cancer. Front Immunol, (2024) 15:1372513 [Link]
[74] H. Chy, R. Biswas, F. Kader, Y. Wan*, and M.A. Iftakher, Design Optimization of Anti-Splashing Targets and Simulation of Droplet Impact on It. Phys Fluids, (2024) 36: 013323 [Link]
[73] G. Wang, T. Li, Y. Wan*, and Q. Li, MYC Expression and Fatty Acid Oxidation in EGFR-TKI Acquired Resistance. Drug Resist Updat, (2024) 72: 101019 [Link]
[72] L. Tong and Y. Wan, A Hybrid Intelligence Approach for Circulating Tumor Cell Enumeration in Digital Pathology by Using CNN and Weak Annotations. IEEE Access, (2023) 11: 142992-143003 [Link]
[71] W. Liu, J. Xu, Z. Pi, Y. Chen, G. Jiang, Y. Wan*, and W. Mao, Untangling the Web of Intratumor Microbiota in Lung Cancer. Biochim Biophys Acta Rev Cancer, (2023) 1878: 189025 [Link]
[70] J. Mei, Y. Cai, G. Jiang, Z. He, R. Wang, C. Song, Y. Wan*, and W. Mao, GPRC5D As A Promising Therapeutic Target In EGFR-Wild And Immuno-Cold Non-Small Cell Lung Cancer. J Transl Med, (2023) 21: 542 [Link]
[69] L. Wang, W. Mao, G. Wang, Y. Chen, M. Rahman, P. Prisinzano, B. Kong, J. Wang, L. Lee, and Y. Wan*, Bioinspired Engineering of Fusogen and Targeting Moiety Equipped Nanovesicles. Nat Comm, (2023) 14: 3366 [Link]
[68] K. Yang, X. Wang, C. Song, Z. He, R. Wang, Y. Xu, G. Jiang, Y. Wan*, J. Mei, and W. Mao, The Role of Lipid Metabolic Reprogramming In The Tumor Microenvironment. Theranotics, (2023) 13: 1774-1808 [Link]
[67] J. Wang, L. Guo, C. Lv, M. Zhou, and Y. Wan*, Developing mRNA Signatures As A Novel Prognostic Biomarker Predicting High Risk Multiple Myeloma. Front Oncol, (2023) 1105196 [Link]
[66] X Wang, Y. Xu, J. Xu, Y. Chen, C. Song, G. Jiang, R. Chen, W. Mao, M. Zheng, and Y. Wan*, Impact of Disparate Pathological Differentiation on Lung Invasive Adenocarcinoma Outcomes: A SEER Cohort-Based Analysis. Transl Cancer Res, (2023) 12: 804-827[Link]
[65] G. Wang, J. Sun, J. Zhang, J. Lu, S. Gao, F. Wang, Q. Yin, Y. Wan*, and Q. Li, Single-Cell Transcriptional Profiling Uncovers The Association Between EOMES+CD8+ T Cell And Acquired EGFR-TKI Resistance. Drug Resist Updat,(2023) 100910 [Link]
[64] J. Wang, C. Lv, M. Zhou, J. Xu, B. Chen, and Y. Wan*, Second Primary Malignancy Risk In Multiple Myeloma From 1975 to 2018. Cancers, (2022) 14:4919 [Link]
[63] J. Mei, Y. Cai, O. Mussafi, M. Zheng, Y. Xu, R. Chen, G. Jiang, W. Mao, W. Xia, and Y. Wan*, Identification of Adenoid Subtype Characterized with Immune-Escaped Phenotype in Lung Squamous Carcinoma Based on Transcriptomics. Exp Hematol Oncol, (2022) 11:70 [Link]
[62] S. Chen, D. Tian, L. Petersen, S. Cao, Z. Quinn, J. Kan, M. Zheng, W. Mao, and Y. Wan*, Prognostic Value of GIMAP4 And Its Role In Promoting Immune Cells Infiltration Into Tumor Microenvironment of Lung Adenocarcinoma. Biomed Res Int, (2022) 2022:7440189 [Link]
[61] J. Wang, Y. Zuo, C. Lv, M. Zhou, and Y. Wan*, N6-Methyladenosine Regulators Are Potential Prognostic Biomarkers for Multiple Myeloma. IUBMB Life, (2022) 75:137-148 [Link]
[60] O. Mussafi, J. Mei, W. Mao, and Y. Wan*, Immune Checkpoint Inhibitors for PD-1/PD-L1 Axis in Combination with Other Immunotherapies and Targeted Therapies for Non-Small Cell Lung Cancer. Front Oncol, (2022) 12:948405 [Link]
[59] Y. Wan*, Y. Xia, and S. Zheng, Extruded Small Extracellular Vesicles: Splinters of Circulating Tumor Cells May Promote Cancer Metastasis? Br J Cancer, (2022) 127:1180-1183 [Link]
[58] L. Yong, S. Tang, H. Yu, H. Zhang, Y. Zhang, Y. Wan*, and F. Cai, The Role of Hypoxia-Inducible Factor-1Alpha in Multidrug-Resistant Breast Cancer. Front Oncol, (2022) 12:964934 [Link]
[57] J. Mei, G. Jiang, Y. Chen, Y. Xu, Y. Wan, R. Chen, F. Liu, W. Mao, M. Zheng, and J. Xu, HLA Class II Molecule HLA-DRA Identifies Immuno-Hot Tumors and Predicts The Therapeutic Response to Anti-PD-1 Immunotherapy. BMC Cancer, (2022) 22:738 [Link]
[56] Y. Wen, Q. Fu, A. Soliwoda, S. Zhang, M. Zheng, W. Mao, and Y. Wan*, Cell-Derived Nanovesicles Prepared By Membrane Extrusion Are Good Substitutes For Natural Extracellular Vesicles. Extracell Vesicles, (2022) 1:100004 [Link]
[55] Y. Chen, Y. Xu, J. Wang, P. Prisinzano, Y. Yuan, F. Lu, M. Zheng, W. Mao, and Y. Wan*, Statins Lower Lipid Synthesis But Promote Secretion of Cholesterol-Enriched Extracellular Vesicles and Particles. Front Oncol, (2022) 12:853063 [Link]
[54] J. Wang, C. Lv, M. Zhou, J. Xu, B. Chen, and Y. Wan*, Primary Central Nervous System Lymphoma in the United States, 1975-2017. Ther Adv Hematol, (2022) 13:1-9[Link]
[53] Y. Chen, L. Wang, M. Zheng, C. Zhu, G. Wang, Y. Xia, E. Blumenthal, W. Mao, and Y. Wan*, Engineered Extracellular Vesicles for Concurrent Anti-PDL1 Immunotherapy and Chemotherapy. Bioact Mater,(2022) 9:251-265 [Link]
[52] G. Wang, W. Hu, Y. Chen, Y. Wan*, and Q. Li, Integrated mPD-L1 and Metabolic Analysis Identifies New Prognostic Subgroups in Lung Cancers with Wild-Type EGFR. Clin Transl Med, (2021) 11: e612 [Link]
[51] Z. Zhang, H. Li, Y. Deng, K. Schuck, S. Raulefs, N. Maeritz, Y. Yu, T. Hechler, A. Pahl, V. Fernandez-Saiz, Y. Wan, G. Wang, T. Engleitner, R. Ollinger, R. Rad, M. Reichert, K. Diakopoulos, V. Weber, J. Li, S. Shen, X. Zou, J. Kleeff, A. Mihaljevic, C. Michalski, H. Algul, H. Friess, and B. Kong, AGR2-Dependent Nuclear Import of RNA Polymerase II Constitutes A Specific Vulnerable Target of Human Cancers Bearing Wild-Type P53. Gastroenterology, (2021) 161:1601-1614 [Link]
[50] H. Zhang, X. Lin, Y. Huang, M. Wang, C. Cen, S. Tang, M. Dique, L. Cai, M. Luis, J. Smollar, Y. Wan, and F. Cai, Detection Methods and Clinical Applications of Circulating Tumor Cells in Breast Cancer. Front Oncol, (2021) 11:652253 [Link]
[49] Y. Liu, Y. Xia, J. Smollar, W. Mao, and Y. Wan*, The Roles of Small Extracellular Vesicles in Lung Cancer: Molecular Pathology Mechanisms, Diagnostics, and Therapeutics. Biochim Biophys Acta Rev Cancer, (2021) 1876:188539 [Link]
[48] K. Abhange, A. Makler, Y. Wen, N. Ramnauth, W. Mao, W. Asghar, and Y. Wan*, Small Extracellular Vesicles in Cancer. Bioact Mater, (2021) 6:3705-3743 [Link]
[47] Q. Zheng, H. Ding, L. Wang, Y. Yan, Y. Wan, Y. Yi, L. Tao, and C. Zhu, Circulating Exosomal miR-96 As A Novel Biomarker for Radioresistant Non-Small-Cell Lung Cancer. J Oncol, (2021)2021:5893981 [Link]
[46] Y. Chen, F. Xue, A. Russo, and Y. Wan*, Proteomic Analysis of Extracellular Vesicles Derived from MDA-MB-231 Cells in Microgravity. Protein J, (2021) 40:108-118 [Link]
[45] Z. Quinn, W. Mao, Y. Chen, G. Wang, Y. Xia, R. John, and Y. Wan*, Conferring Receptors on Recipient Cells with Extracellular Vesicles for Targeted Drug Delivery. Bioact Mater, (2021) 6:749-756 [Link]
[44] F. Xue, Y. Chen, Y. Wen, K. Abhange, W. Zhang, G. Cheng, Z. Quinn, W. Mao, and Y. Wan*, Isolation of Extracellular Vesicles with Multivalent Aptamer. Analyst, (2021) 146: 253-261 [Link]
[43] J. Wang, M. Zhou, J. Xu, R. Zhou, B. Chen, and Y. Wan*, Comparison of Antifungal Prophylaxis Drugs in Patients with Hematological Disease or Undergoing Hematopoietic Stem Cell Transplantation: A Systematic Review and Network Meta-Analysis. JAMA Network Open, (2020) 3:e2017652 [Link]
[42] W. Hu, G. Wang, L. Yarmus, and Y. Wan*, Combined Methylome and Transcriptome Analyses Reveals Potential Therapeutic Targets for EGFR Wild Type Lung Cancers with Low PD-L1 Expression. Cancers, (2020) 12:2496 [Link]
[41] W. Hu, G. Wang, L. An, Y. Chen, L. Yarmus, B. Liu, and Y. Wan*, Coupled Immune Stratification and Identification of Therapeutic Candidates in Patients with Lung Adenocarcinoma. Aging, (2020) 12:16514-16538 [Link]
[40] Y. Wen, Y. Chen, G. Wang, K. Abhange, F. Xue, Z. Quinn, W. Mao, and Y. Wan*, Factors Influencing Measurement the Secretion Rate of Extracellular Vesicles. Analyst, (2020) 145:5870-5877 [Link]
[39] L. Wang, K. Abhange, Y. Wen, Y. Chen, F. Xue, G. Wang, J. Tong, C. Zhu, X. He, and Y. Wan*, Preparation of Engineered Extracellular Vesicles Derived from Human Umbilical Cord Mesenchymal Stem Cells with Ultrasonication for Skin Rejuvenation. ACS Omega, (2019) 4:22638-22645 [Link]
[38] W. Mao, Y. Wen, H. Lei, R. Lu, S. Wang, Y. Wang, R. Chen, Y. Gu, L. Zhu, K. Abhange, Z. Quinn, Y. Chen, F. Xue, M. Zheng, and Y. Wan*, Isolation and Retrieval of Extracellular Vesicles for Liquid Biopsy of Malignant Ground-Glass Opacity. Anal Chem, (2019) 91(21):13729-13736 [Link]
[37] Y. Wan, M. Maurer, H. He, Y. Xia, W. Zhang, N. Yee, and S. Zheng, Enrichment of Extracellular Vesicles Using Lipid Nanoprobes Functionalized Nanostructured Silica. Lab Chip, (2019) 19:2346-2355 [Link]
[36] Y. Wan* and S. Zheng, Enhanced Detection of Tumor-Secreted Vesicles. Nat Biomed Eng, (2019) 3(6):421-422 (News & Views, Invited) [Link]
[35] Y. Xia, Y. Wan, S. Hao, R. A. Harouaka, and S. Zheng, Nucleus of Circulating Tumor Cell Determines Its Translocation Through Biomimetic Microconstrictions and Its Physical Enrichment by Microfiltration. Small, (2018) 14(44):e1802899 [Link]
[34] Y. Wan, B. Liu, H. Lei, B. Zhang, Y. Wang, H. Huang, S. Chen, Y. Feng, L. Zhu, Y. Gu, Q. Zhang, H. Ma, and S. Zheng, Nanoscale Extracellular Vesicle-derived DNA is Superior to Circulating Cell Free DNA for Mutation Detection in Early-stage Non-Small Cell Lung Cancer. Ann Oncol, (2018) 29(12):2379-2383 [Link]
[33] G. Cheng, W. Li, L. Ha, X. Han, S. Hao, Y. Wan, Z. Wang, F. Dong, X. Zou, Y. Mao, and S. Zheng, Self-assembly of Extracellular Vesicle-like Metal-organic Framework Nanoparticles for Protection and Intracellular Delivery of Bio-functional Protein. J Am Chem Soc, (2018) 140(23):7282-7291 [Link]
[32] S. Hao, Y. Wan, Y. Xia, and S. Zheng, Size-based Separation Methods of Circulating Tumor Cells. Adv Drug Deliv Rev, (2018) 125:3-20 (Invited review, Equal Contribution First Author) [Link]
[31] Y. Wan, L. Wang, C. Zhu, G. Wang, Y. Fang, Y. Xia, J. Tong, X. He, and S. Zheng, Aptamer Conjugated Extracellular Nanovesicles for Targeted Drug Delivery. Cancer Res, (2018) 78(3):798-808 [Link]
[30] W. Li, Z. Wang, S. Hao, L. Sun, M. Nisic, G. Cheng, C. Zhu, Y. Wan, L. Ha, and S. Zheng, Mitochondria-based aircraft carrier enhances in vivo imaging of carbon quantum dots and delivery of anticancer drug. Nanoscale, (2018) 10(8):3744-3752 [Link]
[29] S. Hao, L. Ha, G. Cheng, Y. Wan, Y. Xia, D. Sosnoski, A. Mastro, and S. Zheng, A Spontaneous 3D Bone-on-a-chip for Bone Metastasis Study of Breast Cancer Cells. Small, (2018) 14(12):e1702787 [Link]
[28] C. Zhu, L. Wang, Y. Cai, G. Wang, H. Xu, Y. Wan*, and Q. Zheng, Enhancement of Radiation Effect on SMCC7721 Cell through Endoplasmic Reticulum Stress Induced in vitro and in vivo by C225-GNPs. Oncol Lett, (2018) 15(4):4221-4228 [Link]
[27] W. Li, L. Sun, Y. Xia, S. Hao, G. Cheng, Z. Wang, Y. Wan, C. Zhu, H. He, and S. Zheng, Pre-occupation of Empty Carriers Decreases Endo/Lysosome Escape and Reduces the Protein Delivery Efficiency of Mesoporous Silica Nanoparticles. ACS Appl Mater Interfaces, (2018) 10(6):5340-5347 [Link]
[26] Y. Xia, Y. Tang, X. Yu, Y. Wan, Y. Chen, H. Lu, and S. Zheng, Label-free Virus Capture and Release by a Microfluidic Device Integrated with Porous Silicon Nanowire Forest. Small, (2017) 13:1603135, Cover Article [Link]
[25] W. Li, Z. Wang, S. Hao, H. He, G. Cheng, Y. Wan, C. Zhu, L. Sun, G. Cheng and S. Zheng, Mitochondria-targeting Polydopamine Nanoparticles to Deliver Doxorubicin for Overcoming Drug Resistance. ACS Appl Mater Interfaces, (2017) 9(20):16793-16802 [Link]
[24] Y. Wan, G. Cheng, X. Liu, S. Hao, M. Nisic, C. Zhu, Y. Xia, W. Li, Z. Wang, W. Zhang, S. Rice, A. Sebastian, I. Albert, C. Belani, and S. Zheng, Rapid Isolation of Extracellular Vesicles via Lipid-based Nanoprobes. Nat Biomed Eng, (2017) 1(4):0058, Front Cover [Link]
[23] H. Ding, M. Su, C. Zhu, L. Wang, Q. Zheng, and Y. Wan*, CT-guided verses Laparoscopic Radiofrequency Ablation in Recurrent Hepatocellular Carcinoma against the Diaphragmatic Dome. Sci Rep, (2017) 7:44583 [Link]
[22] G. Cheng, S. Hao, Y. Wan, D. Shan, J. Yang and S. Zheng, Self-assembly of Smart Multifunctional Hybrid Compartments with Programmable Bioactivity. Chem Mater, (2017) 29(5):2081-2089 [Link]
[21] W. Ali, M.U. Raza, M.A.I. Mahmood. P.B. Allen, A.R. Hall, Y. Wan, and S.M. Iqbal, Differentiation of Specific Cacner Biomarkers with Solid-state Nanopores. Func Nanostruct, (2016) 26-34 [Link]
[20] C. Zhu, Q. Zheng, L. Wang, H. Xu, J. Tong, Q. Zhang, Y. Wan*, and J. Wu, Synthesis of Novel Galactose Functionalized Gold Nanoparticles and Its Radiosensitizing Mechanism. J Nanobiotechnology, (2015) 13:67 [Link]
[19] H. Ma, J. Liu, M. Ali, F. Li, M. A. I. Mahmood, L. Labanieh, M. Mu, S. M. Iqbal, Q. Zhang, W. Zhao, and Y. Wan*, Nucleic Acid Aptamers in Cancer Research, Diagnosis and Therapy. Chem Soc Rev, (2015) 44(5):1240-1256 [Link]
[18] M. A. I. Mahmood, Y. Wan, M. Islam, W. Ali, M. Hanif, Y. Kim, and S. M. Iqbal, Micro + Nanotexturing of Substrates to Enhance Ligand-assisted Cancer Cell Isolation. Nanotechnology, (2014) 25(47):475102 [Link]
[17] S. Wang, Y. Wan* and Y. Liu, Effects of Nanopillar Array Diameter and Spacing on Cancer Cell Capture and Cell Behaviors. Nanoscale,(2014) 6(21):12482-9, Front Cover [Link]
[16] Y. Wan, M. Winter, B. Delalat, N. H. Voelcker, and B. Thierry, Nanostructured Polystyrene Well Plates Allow Unbiased High-throughput Characterization of Circulating Tumor Cells. ACS Appl Mater Interfaces, (2014) 6(23):20828-20836 [Link]
[15] Y. Wan, S. Apostolou, R. Dronov, B. Kuss, and N. H. Voelcker, Cancer-targeting siRNA Delivery from Porous Silicon Nanoparticles. Nanomedicine,(2014) 9(15):2309-2321 [Link]
[14] Q. Zheng, S. M. Iqbal, and Y. Wan*, Cell Detachment: Post-isolation Challenge. Biotechnol Adv,(2013) 31(8):1664-1675 [Link]
[13] Y. Wan, D. Tamuly, P. B. Allen, Y.-T. Kim, R. Bachoo, A. D. Ellington and S. M. Iqbal, Proliferation and Migration of Tumor Cells in Tapered Channels. Biomed Microdevices, (2013) 15(4):635-643 [Link]
[12] L. Wang, W. Asghar, Utkan Demirci, and Y. Wan*, Nanostructured Substrates for Circulating Tumor Cell Isolation. Nano Today,(2013) 8(4):374-387 [Link]
[11] L. Wang, Q. Zheng, Q. Zhang, H. Xu, J. Tong, C. Zhu and Y. Wan*, Detection of Single Tumor Cell Resistance with Aptamer Biochip. Oncol Lett, (2012) 4(5):935-940 [Link]
[10] Y. Wan, Y. Liu, P. B. Allen, W. Asghar, M. A. I. Mahmood, J. Tan, H. Duhon, Y.-t. Kim, A. D. Ellington and S. M. Iqbal, Capture, Isolation and Release of Cancer Cells with Aptamer-functionalized Glass Bead Array. Lab Chip, (2012) 12(22):4693-701, Cover Article [Link]
[9] W. Asghar, Y.-t. Kim, A. Ilyas, J. S. Sankaran, Y. Wan, P. Abhyankar, and S. M. Iqbal, Synthesis of Nano-textured Biocompatible Scaffolds from Chicken Eggshells. Nanotechnology, (2012) 23(47):475601 [Link]
[8] W. Asghar, Y. Wan, A. Ilyas, Y.-t. Kim and S. M. Iqbal, Electrical Fingerprinting, 3D Profiling and Detection of Tumor Cells with Solid-state Micropores. Lab Chip, (2012) 12(13):2345-2352, Cover Article [Link]
[7] W. Asghar, M. Islam, A. S. Wadajkar, Y. Wan, A. Ilyas, K. T. Nguyen and S. M. Iqbal, PLGA Micro and Nanoparticles Loaded into Gelatin Scaffold for Controlled Drug Release. IEEE Trans Nanotechnol, (2012) 11(3):546-553, Front Cover [Link]
[6] Y. Wan, J. Tan, W. Asghar, Y.-t. Kim, Y. Liu and S. M. Iqbal, Velocity Effect on Aptamers-based Circulating Tumor Cell Isolation in Microfluidic Devices. J Phy Chem B, (2011) 115(47):13891-13896 [Link]
[5] Y. Wan, M. A. I. Mahmood, N. Li, P. B. Allen, Y.-t. Kim, R. Bachoo, A. D. Ellington and S. M. Iqbal, Nanotextured Substrates with Immobilized Aptamers for Cancer Cell Isolation and Cytology. Cancer, (2011) 118(4):1145-1154 [Link]
[4] Y. Wan, Y.-t. Kim, N. Li, S. K. Cho, R. Bachoo, A. D. Ellington and S. M. Iqbal, Surface Immobilized Aptamers for Cancer Cell Isolation and Microscopic Cytology. Cancer Res, (2010) 70(22):9371-9380 [Link]
[3] Y. Wan, Y. Wang, J. Luo, and Z. Lu, Bisulfite Modification of Immobilized DNAs for Methylation Detection. Biosens Bioelectron, (2007) 22(11):241524-21 [Link]
[2] P. Xiao, L. Cheng, Y. Wan, B. Sun, Z. Chen, S. Zhang, C. Zhang, G. Zhou, and Z. Lu, An improved gel-based DNA microarray method for detecting single nucleotide mismatch. Electrophoresis, (2006) 27(19):3904-3915 [Link]
[1] D. Zhou, W. Qiao, Y. Wan, and Z. Lu, Microarray-based Methylation Analysis Using Dual-color Fluorescence Hybridization. J Biochem Biophys Methods, (2006) 66:33-43 [Link]
Conference Proceedings
[47] Y. Wang, Y. Wan*, and R. Li, Adaptive Attention Context Network for Polyp Segmentation. at 3rd International Conference on Image Processing, Computer Vision and Machine Learning, Shenzhen, China (November 22-24, 2024)
[46] M. Rahman and Y. Wan, One-Step Preparation of Immunoliposomes, at 46th Annual International Conference of the IEEE Engineering in Medicine & Biology Society, Orlando, FL USA (July 15-19, 2024)
[45] M. Rahman, Y. Chen, L. Lee, and Y. Wan, Using CRISPR/Cas12 for Point Mutation Detection in Plams EV for Monitoring EGFR-TKI Therapy, at 2nd Annual AAEV Meeting, Boston, MA USA (October 26-29, 2023)
[44] Y. Chen, M. Rahman, and Y. Wan, Fusogen and Targeting Moiety Co-Functionalized Cell-Derived Nanovesicles, at 5th Carnegie Mellon Forum on Biomedical Engineering, Pittsburgh, PA, USA (September 22, 2023)
[43] L. X., Y. Tong, and Y. Wan, Automatic Lung Nodule Classification in CT Images Using Two-Stage CNNs and Soft-Voting of Multi-Scale Classifiers, at 11th European Workshop on Visual Information Processing, Gjovik, Norway (September 11-14, 2023) [Link]
[42] L. Tong and Y. Wan, Deep Learning Combined with Ball Scale Transform for Circulating Tumor Cell Enumeration In Digital Pathology, at SPIE Conference on Digital and Computational Pathology, San Diego, CA USA (February 19-23, 2023) [Link]
[41] L. Tong and Y. Wan, Automatic Circulating Tumor Cell Segmentation and Eneureation in Digital Pathology by Using Deep Learning and Ball-Scale Based Filtering Techniques, at IEEE Singal Processing in Medicine and Biology Symposium, Philadelphia, PA USA (December 3, 2022)
[40] Y. Wen and Y. Wan, Natural Extracellular Vesciels and Extruded Nanovesicles Have Highly Similar Membrane Protein Profiles, at Biomedical Engineering Society Annual Meeting, San Antonio, TX, USA (October 12-15, 2022)
[39] Y. Chen, M. Rahman, and Y. Wan, Construction of Tumor-Targeted Fusogenic Extracellular Vesicles for Cytosolic Delivery of Drugs, at ASEMV2022/AAEV2022, Pacific Grove, CA, USA (September 29-October 3, 2022)
[38] D. Ramos, Y. Chen, and Y. Wan, Atorvastatin Improves Chemosensitivity of SK-OV-3 Cells and Inhibits the Generation of Extracellular Vesicles, at Biomedical Engineering Society Annual Meeting, USA (October 6-9, 2021)
[37] Y. Chen, Y. Wen, E. Blumenthal, K. Abhange, and Y. Wan, Anti-PD-L1 Extracellular Vesicles for Cancer Combination Therapy, at Biomedical Engineering Society Virtual Annual Meeting, (October 6-9, 2021)
[36] Y. Wen, Y. Chen, K. Abhange, F. Xue, and Y. Wan, The Secretion Rate of Extracellular Vesicles and The Related Interfering Factors, at Biomedical Engineering Society Virtual Annual Meeting, (October 14-17, 2020)
[35] F. Xue, Z. Quinn, Y. Chen, R. Joh, and Y. Wan, Conferring Receptors on Cancer Cells with Extracellular Vesicles for Targeted Therapy, at 3rd Carnegie Mellon Forum on Biomedical Engineering, Pittsburgh, PA, USA (September 18-19, 2020)
[34] K. Komal, Y. Wen, Y. Chen, F. Xue, and Y. Wan, The Impact of Simulated Microgravity on Physiochemical Characteritics of MDA-MB-231 Extracellular Vesicles, at 46th Annual Northeast Bioengineering Conference, State College, PA, USA (March 26-28, 2020)
[33] S. Zheng, H. He, F. Wang, and Y. Wan, Extracellular Vesicle-Based Liquid Biopsy via Lipid-Based Nanoprobes, at AACR Special Conference on Advances in Liquid Biopsies, Miami, FL, UAS (January 13-16)
[32] S. Zheng, Y. Wan, M. Maurer, Y. Xia, S. Hao, W. Zhang, and N. Yee, Microfluidic Device Integrated with Lipid Nanoprobe for Extracellular Vesicle Isolation toward Non-invasive Cancer Diagnosis, at AACR Annual Meeting, Atlanta, GA, USA (March 29-April 3, 2019)
[31] D. Bordena, Y. Wen, K. Abhange, Y. Chen, F. Xue, and Y. Wan, Stimulated Microgravity Influences the Size and Release Rate of Extracellular Vesicles, at Biomedical Engineering Society Annual Meeting, Philadelphia, PA, USA (October 16-19, 2019)
[30] Y. Wen, K. Abhange, and Y. Wan, Extracellular Vesicles-based Liquid Biopsy of Pulmonary Ground Glass Opacity, at Biomedical Engineering Society Annual Meeting, Philadelphia, PA, USA (October 16-19, 2019)
[29] K. Abhange, Y. Wen, and Y. Wan, Human Umbilical Cord Mesenchymal Stem Cell Derived Engineered Extracellular Vesicles for Skin Rejuvenation, at Biomedical Engineering Society Annual Meeting, Philadelphia, PA, USA (October 16-19, 2019)
[28] Y. Xia, Y. Wan, Y. Chen, and S. Zheng, Mechanical Generated Extracellular Vesicles through Capillary Mimicking Micro Channels, at Biomedical Engineering Society Annual Meeting, Philadelphia, PA, USA (October 16-19, 2019)
[27] M. Maurer, Y. Wan, H. He, Y. Xia, S. Hao, W. Zhang, N. Yee, and S. Zheng, Enrichment of Extracellular Vesicles via Lipid Nanoprobe-Functionalized Nanostructured Silica Microdevice, at Transducer 2019/EUROSENSORS XXXIII Conference: The 20th International Conference on Solid-State Sensors, Actuators and Microsystems, Estrel Berlin, Germany (June 23-27, 2019)
[26] Y. Wan, M. Maurer, H. He, Y. Xia, W. Zhang, S. Hao, N. Yee, and S. Zheng, A microfluidic Device with Nanoscale Surface Topology and Functionalized with Lipid Nanoprobes for Extracellular Vesicles Isolation and Clinical Cancer Diagnosis, at ISEV 2019, Kyoto, Japan (April 25-28, 2019)
[25] Y. Wen, K. Abhange, and Y. Wan, Rapid and Efficient Isolation of Extracellular Vesicles Towards Clinical Translation, at The 12th Annual Binghamton Biomedical Research Conference, Binghamton, NY, USA (March 23, 2019)
[24] Y. Wen, K. Abhange, and Y. Wan, Detection of DNA Mutations in Extracellular Vesicles Derived from Patients with Malignant Ground Glass Opacities, at The 45th Annual Northeast Bioengineering Conference, New Brunswich, NJ, USA (March 20-22, 2019)
[23] K. Abhange, Y. Wen, and Y. Wan, Engineered Extracellular Vesicles Derived from Human Umbilical Cord Mesenchymal Stem Cells for Skin Rejuvenation, at The 45th Annual Northeast Bioengineering Conference, New Brunswich, NJ, USA (March 20-22, 2019)
[22] Y. Wen, K. Abhange, and Y. Wan, Next Generation Sequencing Analysis of Extracellular Vesicles Derived DNA from 8 Patients with Ground-Glass Opacity, at Translational Genomics & Proteomics: An Un-Meeting, Rochester, NY, USA (March 13, 2019)
[21] M. Maurer, Y. Wan, H. He, Y. Xia, S. Hao, W. Zhang, N. Yee, and S. Zheng, Lipid-Nanoprobe Functionalized Silica Nanostructured Microdevice for Exosome Enrichment, at Biomedical Engineering Society Annual Meeting, Atlanta, Georgia, USA (October 17-20, 2018)
[20] M. Maurer, W. Zhang, Y. Wan, and S. Zheng, Fractionation and Enrichment of Extracellular Vesicles via a Carbon Nanotube Microdevice, at Biomedical Engineering Society Annual Meeting, Atlanta, Georgia, USA (October 17-20, 2018)
[19] S. Hao, L. Ha, G. Cheng, Y. Wan, Y. Xia, D. Sosnoski, A. Mastro, and S. Zheng, A Spontaneous 3D Bone-On-a-Chip for Bone Metastasis Study of Breast Cancer Cells, at Biomedical Engineering Society Annual Meeting, Atlanta, Georgia, USA (October 17-20, 2018)
[18] W. Li, L. Sun, Y. Xia, S. Hao, G. Cheng, Z. Wang, Y. Wan, C. Zhu, H. He, and S. Zheng, Preoccupation of Empty Carriers Decreases Endo-/Lysosome Escape and Reduces the Protein Delivery Efficiency of Mesoporous Silica Nanoparticles, at Biomedical Engineering Society Annual Meeting, Atlanta, Georgia, USA (October 17-20, 2018)
[17] Y. Xia, Y. Wan, S. Hao, and S. Zheng, Nuclei’s Role in Cell Translocation Through Micro-restrictions, at 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2017 Conference, Savannah, Georgia, USA (October 22-26, 2017)
[16] Y. Wan and S. Zheng, Rapid Isolation of Extracellular Vesicles with Lipid Nanoprobes, at Biomedical Engineering Society Annual Meeting, Phoenix, Arizona, USA (October 11-14, 2017)
[15] G. Cheng, S. Hao, Y. Wan, and S. Zheng, Self-assembly of Smart Multifunctional Hybrid Compartments with Programmable Bioactivity, at Biomedical Engineering Society, Phoenix, Arizona, USA (October 11-14, 2017)
[14] G. Cheng, S. Hao, Y. Wan, D. Shan, J. Yang and S. Zheng, Smart Magnetic Colloidosomes as Multifunctional Microreactors for Programming Biomolecular Activity, at 254th American Chemical Society National Meeting & Exposition, Washington, DC, USA (August 20-24, 2017)
[13] S. Hao, G. Cheng, Y. Wan and S. Zheng, A Bone-on-a-chip Microdevice for Long-term Spontaneous 3D Bone Tissue Formation and Cancer Bone Metastasis, at 19th International Conference on Solid-State Sensors, Actuators and Microsystems, Kaohsiung, Taiwan (June 18-22, 2017)
[12] Q. Zheng, H. Ding, C. Zhu, L. Wang, and Y. Wan*, Retrospective Study of CT-guided verses Laparoscopic Radiofrequency Ablation in Recurrent Hepatocellular Carcinoma against the Diaphragmatic Dome, at Gastrointestinal Cancers Symposium, San Francisco, California, USA (January 19-21, 2017)
[11] Q. Zheng, H. Ding, C. Zhu, L. Wang, and Y. Wan*, CT-guided verses Laparoscopic Radiofrequency Ablation in Recurrent Hepatocellular Carcinoma against the Diaphragmatic Dome, at ESMO Asia, Singapore, (December 16-19, 2016)
[10] S. Wang, Y. Wan, Y. Liu, Effects of Nanopillar Array Geometry on Capture and Detachment of Circulating Tumor Cells, at 7th World Congress of Biomechanics, Boston, MA, USA (July 6-11, 2014)
[9] Y. Wan and B. Thierry, Rapid and Efficient Binding of Cancer Cells on Nanostructured Polystyrene for Morphological and Molecular Analysis, at 23rd Australian Conference on Microscopy and Microanalysis (ACMM23) and the International Conference on Nanoscience and Nanotechnology (ICONN), Adelaide, SA, Australia (February 2-6, 2014)
[8] Y. Wan, S. Apostolou, B. Kuss, R. Dronov and N.H. Voelcker, Amino-functionalized Porous Silicon Nanoparticles for Loading and Release of siRNA, at 22nd ASBTE with 5th Indo-Australian Conference on Biomaterials, Implants and Tissue Engineering, Barossa Valley, SA, Australia (April 2-5, 2013)
[7] M. A. I. Mahmood, U. J. M. Khan, Y. Wan, Y.-t. Kim and S. M. Iqbal, Metastatic Tumor Cells Show Distinct Behavior on Aptamer Functionalized Chips, at Biomedical Engineering Society Annual Meeting, Atlanta, GA, USA (October 24-27, 2012)
[6] Y. Wan, Y.-t. Kim, N. Li, A. D. Ellington, R. Bachoo and S. M. Iqbal, Novel Solid-State Coatings for Cancer Cell Isolation and Cytology, at 27th Southern Biomedical Engineering Conference (SBEC), Arlington, TX, USA (April 29-May 1, 2011)
[5] Y. Wan, Y.-t. Kim, N. Li, A. D. Ellington, R. Bachoo and S. M. Iqbal, Surface texturing and molecular functionalization for cancer cell isolation, at World’s Best Technologies Innovation Marketplace, Arlington, TX, USA (March 22-23, 2011)
[4] R. A. Khan, W. Asghar, Y. Wan, and S. M. Iqbal, Single Pore System for Classification of Cells, at Biomedical Engineering Society Annual Meeting, Austin, TX, USA (October 6-9, 2010)
[3] Y. Wan, Y.-t. Kim, N. Li, A. D. Ellington and S. M. Iqbal, Aptamer-based Lab-on-Chip for Cancer Cell Isolation and Detection, at Proc. of ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology (NEMB 2010), Houston, TX, USA (February 7-10, 2010)
[2] Y. Wang, Y. Wan, W. Zheng, Z. Lu, The Feasibility of in situ Bisulfate Modification for Genomic DNA Methylation Detection, at Proc. of4 thInternational Forum on Post-genome Technologies, Hangzhou, China (September 25-26, 2006)
[1] Y. Wan, Y. Wang, J. Luo and Z. Lu, Detection of p16 Promoter Methylation Using Acrylamide Modified Nucleic Acids Microarray, in Proc. of4thInternational forum on post-genome technologies, Hangzhou, China (September 25-26, 2006)
Book Chapter
[2] Y. Wan, M. Maurer, S. Zheng, Affinity-Based Enrichment of Extracellular Vesicles with Lipid Nanoprobes. Biomed Eng Technol, (2022) 185-197 [Link]
[1] M. A. I. Mahmood, Y. Wan, and S. M. Iqbal, Micro/Nanostructured Substrates for Cancer Cell Typing, Isolation and Disease Diagnostics in Nanotechnology, Biosensors and Disease Biomarkers: New Approaches to enable Personalized, Preventative and At-Home Medicine, Editors: M. J. A. Shiddiky and M. Trau, Nova Science Publishers Inc., USA (2013)
Invited Talks & Seminars
[9] "Engineered Cell-Derived Nanovesicles for Cancer Therapy", Stony Brook University, Oct 23, 2023
[8] "Small Extracellular Vesicles As Diagnostic and Therapeutic Tools", Upstate Medical University, Nov 11, 2022
[7] "Small Extracellular Vesicles As Diagnostic and Therapeutic Tools", George Mason University, Apr 14, 2022
[6] "Small Extracellular Vesicles As Diagnostic and Therapeutic Tools", Brigham and Women's Hospital, Engineering in Medicine Division, Harvard Medical School, Mar 23, 2022
[5] "Small Extracellular Vesicles As Diagnostic and Therapeutic Tools", Rutgers University, Mar 4, 2022
[4] "Early Diagnosis of Malignant Pulmonary Nodules" Trial Site News, Dec 6 2021
[3] "Optimal Antifungal Prophylactic Agents for Patients with Hematologic Diseases". i3Health News, Oct 9, 2020
[2] "Extracellular Vesicles in Cancer Diagnostics and Therapeutics", Northeast BME Early-Career Faculty Seminar, at Stevens Institute of Technology, Nov 19, 2019.
[1] "Extracellular Vesicles in Cancer Diagnostics and Therapeutics", Graduate Seminar, Binghamton University, Sep 24, 2018
Patents
[4] Y. Wan and M. Rahman, Smart Self-Assembly of A Chimeric Nanobody-Decorated Liposome, 63/552,527
[3] S. Zheng, Y. Wan, and G. Cheng, Lipid Nanoprobes for Isolation of Extracellular Vesicles, US Patent App. No. PCT/US2017/064634
[2] S. Iqbal, S. Goyal, Y. Kim, Y. Wan, M.A.I. Mahmood, and U.J.M. Khan, Methods of Detection Tumor Cells, US Patent App. No. US2015/0010912
[1] S. Iqbal, S. Goyal, Y. Kim, and Y. Wan, Nano-scale Biosensors, US Patent No. US8940663